Connecting iron regulation and mitochondrial function in Cryptococcus neoformans.
Identifieur interne : 000184 ( Main/Exploration ); précédent : 000183; suivant : 000185Connecting iron regulation and mitochondrial function in Cryptococcus neoformans.
Auteurs : Linda C. Horianopoulos [Canada] ; James W. Kronstad [Canada]Source :
- Current opinion in microbiology [ 1879-0364 ] ; 2019.
Descripteurs français
- KwdFr :
- Cryptococcus neoformans (métabolisme), Fer (métabolisme), Ferrosulfoprotéines (métabolisme), Glutarédoxines (métabolisme), Mitochondries (métabolisme), Oligoéléments (métabolisme), Régulation de l'expression des gènes fongiques (MeSH), Transport biologique (MeSH), Voies et réseaux métaboliques (MeSH).
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Glutaredoxins, Iron, Iron-Sulfur Proteins, Trace Elements.
- metabolism : Cryptococcus neoformans, Mitochondria.
- Biological Transport, Gene Expression Regulation, Fungal, Metabolic Networks and Pathways.
Abstract
Iron acquisition is essential for the proliferation of microorganisms, and human pathogens such as the fungus Cryptococcus neoformans must use sophisticated uptake mechanisms to overcome host iron sequestration. Iron is of particular interest for C. neoformans because its availability is an important cue for the elaboration of virulence factors. In fungi, extracellular iron is taken up through high affinity, low affinity, siderophore-mediated, and heme uptake pathways, and the details of these mechanisms are under active investigation in C. neoformans. Following uptake, iron is transported to intracellular organelles including mitochondria where it is used in heme biosynthesis and the synthesis of iron-sulfur (Fe-S) cluster precursors. One Fe-S cluster binding protein of note is the monothiol glutaredoxin Grx4 which has emerged as a master regulator of iron sensing in C. neoformans and other fungi through its influence on the expression of proteins for iron uptake or use. The activity of Grx4 likely occurs through interactions with Fe-S clusters and transcription factors known to control expression of the iron-related functions. Although the extent to which Grx4 controls the iron regulatory network is still being investigated in C. neoformans, it is remarkable that it also influences the expression of many genes encoding mitochondrial functions. Coupled with recent studies linking mitochondrial morphology and electron transport to virulence factor elaboration, there is an emerging appreciation of mitochondria as central players in cryptococcal disease.
DOI: 10.1016/j.mib.2019.04.002
PubMed: 31085406
PubMed Central: PMC6842668
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Kronstad</name><affiliation wicri:level="4"><nlm:affiliation>Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, 2185 East Mall, Vancouver, BC V6T 1Z4, Canada. 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Iron is of particular interest for C. neoformans because its availability is an important cue for the elaboration of virulence factors. In fungi, extracellular iron is taken up through high affinity, low affinity, siderophore-mediated, and heme uptake pathways, and the details of these mechanisms are under active investigation in C. neoformans. Following uptake, iron is transported to intracellular organelles including mitochondria where it is used in heme biosynthesis and the synthesis of iron-sulfur (Fe-S) cluster precursors. One Fe-S cluster binding protein of note is the monothiol glutaredoxin Grx4 which has emerged as a master regulator of iron sensing in C. neoformans and other fungi through its influence on the expression of proteins for iron uptake or use. The activity of Grx4 likely occurs through interactions with Fe-S clusters and transcription factors known to control expression of the iron-related functions. Although the extent to which Grx4 controls the iron regulatory network is still being investigated in C. neoformans, it is remarkable that it also influences the expression of many genes encoding mitochondrial functions. Coupled with recent studies linking mitochondrial morphology and electron transport to virulence factor elaboration, there is an emerging appreciation of mitochondria as central players in cryptococcal disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31085406</PMID><DateCompleted><Year>2020</Year><Month>07</Month><Day>28</Day></DateCompleted><DateRevised><Year>2020</Year><Month>07</Month><Day>28</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-0364</ISSN><JournalIssue CitedMedium="Internet"><Volume>52</Volume><PubDate><Year>2019</Year><Month>12</Month></PubDate></JournalIssue><Title>Current opinion in microbiology</Title><ISOAbbreviation>Curr Opin Microbiol</ISOAbbreviation></Journal><ArticleTitle>Connecting iron regulation and mitochondrial function in Cryptococcus neoformans.</ArticleTitle><Pagination><MedlinePgn>7-13</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1369-5274(18)30090-0</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.mib.2019.04.002</ELocationID><Abstract><AbstractText>Iron acquisition is essential for the proliferation of microorganisms, and human pathogens such as the fungus Cryptococcus neoformans must use sophisticated uptake mechanisms to overcome host iron sequestration. Iron is of particular interest for C. neoformans because its availability is an important cue for the elaboration of virulence factors. In fungi, extracellular iron is taken up through high affinity, low affinity, siderophore-mediated, and heme uptake pathways, and the details of these mechanisms are under active investigation in C. neoformans. Following uptake, iron is transported to intracellular organelles including mitochondria where it is used in heme biosynthesis and the synthesis of iron-sulfur (Fe-S) cluster precursors. One Fe-S cluster binding protein of note is the monothiol glutaredoxin Grx4 which has emerged as a master regulator of iron sensing in C. neoformans and other fungi through its influence on the expression of proteins for iron uptake or use. The activity of Grx4 likely occurs through interactions with Fe-S clusters and transcription factors known to control expression of the iron-related functions. Although the extent to which Grx4 controls the iron regulatory network is still being investigated in C. neoformans, it is remarkable that it also influences the expression of many genes encoding mitochondrial functions. Coupled with recent studies linking mitochondrial morphology and electron transport to virulence factor elaboration, there is an emerging appreciation of mitochondria as central players in cryptococcal disease.</AbstractText><CopyrightInformation>Copyright © 2019 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Horianopoulos</LastName><ForeName>Linda C</ForeName><Initials>LC</Initials><AffiliationInfo><Affiliation>Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, 2185 East Mall, Vancouver, BC V6T 1Z4, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kronstad</LastName><ForeName>James W</ForeName><Initials>JW</Initials><AffiliationInfo><Affiliation>Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, 2185 East Mall, Vancouver, BC V6T 1Z4, Canada. 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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31085406" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a GlutaredoxinV1
| This area was generated with Dilib version V0.6.37. |  |